Staphylococcus Research Today is a free monthly online journal that collates and summarizes the latest research about Staphylococcus, including details on mrsa, hospitals, infection, antibiotic resistance, superbugs.

Evaluation of the antimicrobial mode of berberine by LC/ESI-MS combined with principal component analysis.

Yi ZB, Yan Yu , Liang YZ, Bao Zeng

College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Medicines, Central South University, ChangSha 410083, PR China.

In this investigation, metabolic profiles of Staphylococcus aureus treated by berberine and nine antibacterial substances with known modes of action were acquired by HPLC/ESI-MS. After data pretreatment, those profiles acquired were reduced into several MS vectors. Then, principal component analysis was carried out upon those vectors to classify those drugs according to their mechanisms. From the result obtained by principal component analysis, the possible antibacterial mode of berberine was evaluated.

Published 16 April 2007 in J Pharm Biomed Anal, 44(1): 301-4.
Full-text of this article is available online (may require subscription).

© 2004-2008 Staphylococcus Research Today. All Rights Reserved.