Staphylococcus Research Today is a free monthly online journal that collates and summarizes the latest research about Staphylococcus, including details on mrsa, hospitals, infection, antibiotic resistance, superbugs. | ||||||||
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Intranasal corticosteroid use is associated with lower rates of bacterial recovery in chronic rhinosinusitis.Desrosiers M, Hussain A, Frenkiel S, Kilty S, Marsan J, Witterick I, Wright E Canadian Society of Otololaryngology-Head and Neck Surgery Rhinology group and Department of Otolaryngology, Hotel-Dieu de Montreal, Montreal, Quebec, Canada. desrosiers_martin@hotmail.com OBJECTIVE: To determine whether use of a topical intranasal corticosteroid (INCS) preoperatively had an effect on the bacterial recovery rate and flora recovered at endoscopic sinus surgery (ESS). STUDY DESIGN AND SETTING: A prospective, multicenter, observational study from academic-based rhinology practices. Consecutive, unselected patients undergoing ESS had protected sinus cultures done at the time of ESS. RESULTS: 157 patients were assessed. Overall growth rate was 45.5%. INCS users had a positive culture rate of 35.4% vs 61.7% in nonusers (P = 0.0001). This effect was most pronounced in the subgroup undergoing revision surgeries (bacterial recovery rate INCS: 40.0%, no INCS: 82.6%, P = 0.001) and most marked for S. aureus (INCS: 12.5%, no INCS: 40.0%, P = 0.04) and CNS (INCS: 12.5%, no INCS: 30.4%, P = 0.05). While the rate of nasal polyposis was higher in both revision and the INCS-treated groups, rate of bacterial recovery was not influenced by a diagnosis of nasal polyposis. CONCLUSION: INCS use preoperatively is associated with a lesser rate of bacterial recovery at the time of ESS, especially in individuals with previous ESS. SIGNIFICANCE: The results suggest a possible role of INCS in the management of post-ESS disease. Published 9 April 2007 in Otolaryngol Head Neck Surg, 136(4): 605-9.
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