Staphylococcus Research Today is a free monthly online journal that collates and summarizes the latest research about Staphylococcus, including details on mrsa, hospitals, infection, antibiotic resistance, superbugs.

Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycle.

Chatterjee I, Herrmann M, Proctor RA, Peters G, Kahl BC

Institute of Medical Microbiology and Hygiene, University of Saarland, Kirrberger Str., Building 43, Homburg/Saar 66421, Germany. ichatterjee76@yahoo.com

The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

Published 19 March 2007 in J Bacteriol, 189(7): 2936-40.
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