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Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains.

Wootton M, Macgowan AP, Walsh TR

Department of Pathology and Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, Medical Sciences, University of Bristol, and North Bristol Healthcare Trust, Southmead Hospital, Bristol, UK. mandy.wootton@bristol.ac.uk

Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.

Published 25 November 2005 in Biochim Biophys Acta, 1726(3): 326-7.
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