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Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms.

Johnson M, Cockayne A, Williams PH, Morrissey JA

Department of Genetics, University of Leicester, UK. jam26@le.ac.uk.

We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.

Published 18 November 2005 in J Bacteriol, 187(23): 8211-5.
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