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Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.

Moore CE, Segal S, Berendt AR, Hill AV, Day NP

Nuffield Department of Clinical Medicine, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom. catrin.moore@paediatrics.ox.ac.uk

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.

Published 12 November 2004 in Clin Diagn Lab Immunol, 11(6): 1194-7.
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